Research Assistant I – Shrestha Auditory Research – Mass. Eye and Ear (MEE) – Boston, MA

Shrestha Auditory Physiology & Plasticity Research

The Shrestha Lab at Mass Eye and Ear/Harvard Medical School studies mechanisms that orchestrate plasticity and stability of multiple facets of neuronal identities in the mouse auditory system, using cutting-edge molecular genetic approaches such as scRNA-seq, scATAC-seq, and CRISPR/Cas9-based genomic editing.

Job Description:

We are looking for a Research Assistant to assist us across various projects in the laboratory. The candidate will be primarily responsible for: 1) regular handling of live mice for the purpose of setting up crosses, weaning litters, collecting tissue samples for genotyping, injecting anaesthetics and other drugs, 2) extracting, dissecting, processing and sectioning brain tissues, 3) detecting mRNA and proteins of interest by in situ hybridization and immunohistochemistry, 4) preparing buffers and reagents for molecular biology, 5) gel electrophoresis and imaging, 6) acquiring images using epifluorescence and confocal microscopy, 7) assisting in general laboratory maintenance, including setting up of equipments, and organizing reagents and supplies. Offering a broad exposure to standard techniques employed in a molecular neuroscience lab, this position is ideal for individuals seeking to pursue graduate studies in biomedical sciences or medicine.

About Us:

As a not-for-profit organization, Mass General Brigham is committed to supporting patient care, research, teaching, and service to the community by leading innovation across our system. Founded by Brigham and Women’s Hospital and Massachusetts General Hospital, Mass General Brigham supports a complete continuum of care including community and specialty hospitals, a managed care organization, a physician network, community health centers, home care and other health-related entities. Several of our hospitals are teaching affiliates of Harvard Medical School, and our system is a national leader in biomedical research.

We’re focused on a people-first culture for our system’s patients and our professional family. That’s why we provide our employees with more ways to achieve their potential. Mass General Brigham is committed to aligning our employees’ personal aspirations with projects that match their capabilities and creating a culture that empowers our managers to become trusted mentors. We support each member of our team to own their personal development—and we recognize success at every step.

Our employees use the Mass General Brigham values to govern decisions, actions and behaviors. These values guide how we get our work done: Patients, Affordability, Accountability & Service Commitment, Decisiveness, Innovation & Thoughtful Risk; and how we treat each other: Diversity & Inclusion, Integrity & Respect, Learning, Continuous Improvement & Personal Growth, Teamwork & Collaboration.


Bachelor’s degree with at least six months of relevant work experience required. Comfort with handling live mice and performing procedures on anesthetized mice is a must. Demonstrated abilities in relevant laboratory techniques with one or more years of experience in the stated techniques preferred. May be required to work with hazardous materials. May occasionally be required to lift, move, and transport laboratory equipment. The ideal candidate is detail-oriented, has excellent organizations skills, can multi-task efficiently, and loves to learn new concepts and techniques related to studies of the nervous system.

EEO Statement

EEO Statement:

Mass General Brigham is an Equal Opportunity Employer & by embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law.

Work Locations
MEI Mass Eye and Ear Main Building Boston 243 Charles Street Boston 02114

Mass. Eye and Ear (MEE)

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