Postdoctoral Researcher – POSTDOC – Albert Einstein College of Medicine – New York, NY

Postdoctoral Position in Cardiovascular and Metabolic Research

Job Title: Postdoctoral Research Position at Albert Einstein College of Medicine, New York City (NY).

Job Description: Positions of postdoctoral scientists are available in Dr. Santulli’s lab at the Albert Einstein College of Medicine.
Dr. Gaetano Santulli, MD, PhD is a member of the following Departments and Institutes:

-Department of Medicine (Division of Cardiology),
-Department of Molecular Pharmacology,
-Einstein/Sinai Diabetes Research Center (ES-DRC),
-Wilf Family Cardiovascular Research Institute,
-Fleischer Institute for Diabetes and Metabolism.

The Santulli laboratory has interest in understanding the cellular and molecular mechanisms of cardiovascular and metabolic disorders, including heart failure, diabetes mellitus, hypertension, atherosclerosis, and obesity; we are also investigating the translational application into the clinical scenario of non-coding RNAs, epigenetics, stem cells, and oxidative stress.

The lab is well funded by the NIH and the AHA (3 R01s, 1 R56, 1 R00, 1 T32).

Recent publications summarizing the lines of research in the Santulli’s lab:
-Role of Endothelial GRK2 in angioedema. Hypertension 2020; 10.1161/HYPERTENSIONAHA.120.15130

-Genetics of Adrenergic Signaling Drives Coronary Artery Calcification. Atherosclerosis 2020; 10.1016/j.atherosclerosis.2020.07.025

-miR-7 Regulates GLP-1-Mediated Insulin Release by Targeting Beta-Arrestin 1. Cells 2020; 10.3390/cells9071621

-Cardiac BIN1 Replacement Therapy Ameliorates Inotropy and Lusitropy in Heart Failure by Regulating Calcium Handling.
JACC Basic Transl Sci. 2020; 10.1016/j.jacbts.2020.03.018

-Standardizing Translational Microbiome Studies and Metagenomics Analyses. Cardiovascular Research 2020; 10.1093/cvr/cvaa175

-A Small Molecule Allosteric Inhibitor of BAX Protects Against Doxorubicin-induced Cardiomyopathy.
Nature Cancer 2020; 10.1038/s43018-020-0039-1

-Metabolic Flexibility of Mitochondria Plays a Key Role in Balancing Glucose and Fatty Acid Metabolism in the Diabetic Heart. Diabetes 2020; 10.2337/dbi20-0024

-Cardiomyocyte-derived Exosomal miR-92a Mediates Post-ischemic Myofibroblast Activation. ESC Heart Fail. 2020; 10.1002/ehf2.12584

-Catheter Ablation Improved Quality of Life More Than Drug Therapy at 1y in Symptomatic Atrial Fibrillation.
Ann Intern Med 2019; 10.7326/ACPJ201907160-010

-Safety in Numbers: Identifying Multiple Targets for Beta Cell Proliferation.
Science Transl Medicine. 2019; 10.1126/scitranslmed.aaw5312

-Ryanodine Receptor Calcium Leak in Circulating B-Lymphocytes as a Biomarker in Heart Failure.
Circulation 2018; 10.1161/CIRCULATIONAHA.117.032703

-Impaired Mitochondrial Calcium Uptake Caused by Tacrolimus Underlies Beta-cell Failure. Cell Commun 2017; 10.1186/s12964-017-0203-0

-Maintenance of Normal Blood Pressure is Dependent on IP3R1-mediated Regulation of eNOS. PNAS 2016; 10.1073/pnas.1608859113

-Calcium Release Channel RyR2 Regulates Insulin Release and Glucose Homeostasis. JCI 2015; 10.1172/JCI79273

-Mitochondrial Calcium Overload is a Key Determinant in Heart Failure. PNAS 2015; 10.1073/pnas.1513047112

-β-Blockers in Diabetic Patients with Heart Failure. JAMA Intern Med 2015; 10.1001/jamainternmed.2014.8009

-Genetically Enhancing Mitochondrial Antioxidant Activity Improves Muscle Function in Aging. PNAS 2014; 10.1073/pnas.1412754111

-A Selective microRNA-based Strategy Inhibits Restenosis while Preserving Endothelial Function. JCI 2014; 10.1172/JCI76069

More info on the Santulli lab may be found at: https://www.researchgate.net/profile/Gaetano_Santulli/research

Duties and Responsibilities:
-Design and perform experiments
-Data analysis, interpretation, and presentation
-Report progress regularly
-Write manuscripts and grant applications

Desired Skills:
-Candidates should have completed PhD training or equivalent, and have independent research ability, robust research interest, ambitious scientific goals, and self-motivation.
-Hands-on experience with cell cultures, preclinical studies, and statistics.
-Ability to work in a research-intensive and fast-paced environment.
-Strong writing and communication skills.

Successful applicant(s) will be provided with sufficient support and freedom to ask important research questions and independently develop innovative research projects, will be offered a generous NIH guideline-based salary and benefits, in addition to being a member of a high-quality research team and a collaborative research environment of NIH-sponsored diabetes center and cardiovascular institute. The Belfer Institute for Advanced Biomedical Studies at Einstein also provides an optimal scientific and social environment as well as convenient housing options for postdoctoral researchers.

Established in 1953, Albert Einstein College of Medicine is well recognized as one of the nation’s premier institutions for medical education, basic research, and clinical investigation. Its NIH funding per investigator ranks very high (7th among US universities). As a longstanding national leader in biomedical research, Einstein has more than 300 research laboratories, 3,000 faculty and staff, and offers many exciting career opportunities for individuals like postdoctoral scientists who are dedicated to biomedical research. Albert Einstein College of Medicine is an equal opportunity employer committed to workforce diversity.

Application material:
-Updated CV with list of publications
-1-page cover letter with Research statement
-Contact information to obtain 3 reference letters

Documents and inquiries must be sent via email to Dr. Santulli:
gsantulli001 (AT) gmail.com

The Albert Einstein College of Medicine is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran or disabled status, or genetic information. Einstein seeks candidates whose skills and personal and professional experience have prepared them to contribute to our commitment to diversity and excellence, and the communities we serve.

Job Type: Full-time

Pay: $50,004.00 – $60,004.00 per year

Benefits: